5/31/2023 0 Comments Virus cultivation in cell cultureUnlike the other currently recognized human CoVs, HCoV-229E, HCoV-OC43, HCoV-NL63, and HKU1, which usually cause mild upper respiratory tract infections and occasionally pneumonia in older adults, neonates, and immunocompromised patients ( 5 – 8), SARS-CoV causes severe febrile lower respiratory tract illness that leads to pneumonia and acute respiratory distress ( 9, 10). Several wildlife species consumed as delicacies in southern China, including Himalayan masked palm civets, Chinese ferret badgers, and raccoon dogs, possess antibodies consistent with natural infection with related CoVs ( 4). Although the origins of the virus have not been established, evidence suggests that it is an animal virus that was recently transmitted to humans ( 3). A novel coronavirus (CoV), designated SARS-CoV, was quickly identified as the etiologic agent ( 1, 2). Severe acute respiratory syndrome (SARS) was first observed in 2002 when cases of a life-threatening atypical pneumonia occurred in Guangdong Province, China ( 1).
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